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Dsmmcm, this is just one subjective experience, but whenever i combine tagamet (inhibits tramadol metabolism) with tramadol, i feel like im about to go insane and lose my mind and pace around praying i wont black out before xanax kicks in. I believe poor metabolisers would be much more prone to possible seizures.
Thanks. I don't take tagamet, but I am on a daily dose of prevacid. Fortunately, it is not a H2-receptor antagonist, like tagamet.
D.