Thanks for the info. One of the problems with the PDR is that once something gets in, it never gets out. Plus, every single side effect that has every been reported, real or not, is listed in the PDR. I seriously doubt that your two friends suffered seizures from tramadol. My doc has had about 1000 patients on tramadol, with no seizures. When he first gave me a prescription for tramadol, I didn't fill it, because I was worried about the seizure issue. The next time I saw him, he gave me a ten minute lecture on how safe tramadol is. I now take 50 mg four times a day.