timberland
(Enthusiast)
08/25/04 06:38 PM
Re: Oxycodone - Oxycontin

Quote:

YEs reading up on how the various dopamine receptors (primaririly mu(u) and kappa(k1) plus 12 others are BLOCKED by pain killers like oxy and morphine makes for good reading. the main difference between oxy and morph is that oxy is not rendered 70-80% into inert or ineffective substances like morphine is , when taken orally.

and i AM ABSOLUTELY SURE THAT NO AMOUNT OF SUPPLIMENT/CLEAN LIVING WILL PUT CARTALIGE BACK INBETWEEN MY VERTEBREA.

lOOK UP "pRINCIPLES OF DRUG ACTION 2, fALL 2000" BY jACK dErUITER. Sorry caps. I found if from a link on the DB last week




Yikes, guys, endorphins are different than dopamine! Endorphins are small polypeptides that bind to opiate receptors (mu, delta, kappa). Binding to opiate receptors inhibits the neurons that carry the receptors. In a part of the brain called the ventral tegmental area, there are neurons that inhibit dopamine input to a place called the nucleus accumbens. Opiates and endorphins shut down this inhibition and let dopamine flow freely, which gets you high or at least makes you want to take more.



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