The trick with Midrin is to take two at a time, along with a Fiorcet. I suffered from brutal migranes years ago, and a headache doctor prescribed that combo for me. As long as I could take it at the very first sign of a headache, it usually would work -- but not for those worst, hiding-in-the-dark-because-you-feel-so-sick-and-can't-take-the-light migranes.