I agree Watsons are best,then brand,then Mallie. I also agree that the 7.5/500 work better for me at times than the 10/500. It especially works great to rotate them.One time get 10's when that consult runs out do 7.5's, etc. My dentist always writes me for 15 10/500's when I have any work done and my mom &pop pharm gives me the pink brand and they work ok. I have noticed that the mallies give me a horrible headache, I think the true effectiveness of the hydro depends on the amt of acetomen. that it is mixed with.JMO..