and tramadol withdrawal may be a bit like effexor withdrawal combined opioid withdrawal since one of the mechanisms also involves reuptake of norepinephrine and serotonin. of course its not going to be just like effexor just because they both reuptake NE and 5-HT, the brain has many different sites and areas and drugs that have the same mechanism usually only have similar, but not the exact same effects.

Ive gotten dependant on tramadol from 50 mg a day only. It hits me harder than hydro or oxy, except for the little 15 -30 minute peak of hydro and oxy. only during that short peak are the other opioids stronger than tramadol. All other times, tramadol is much stronger. never tried time released for the others.