| tone |
| (Old Hand) |
| 10/17/04 09:08 PM |
 Re: Tramadol (Ultram)
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Quote:
I'm curious, if Tramadol's theraputic effect is similar to Codeine in potency, and it is acknowledged that it has potential for dependence and withdrawl, why is it not a Scheduled controlled substance?
Well, dependance and withdrawal doesnt seem to be an issue in if it should be controlled, look at paxil and others.
tramadol was reviewed by some board, i forgot which, whoever reviews these sorts of things, and they decided not to make it controlled. When one takes tramadol the onset is drawn out over like 2 hours, so you go from no opioid activity, to its full potential in 2 hours or so. with hydrocodone and oxycodone, once the onset begins, you go up to its full effects in like 15 minutes, so theres more of the "rush" factor. like 7 or 8 times more if you go by how long the onset is. In the prescribing info monograph of tramadol it notes:
Quote:
Part of tramadol's activity and some extension of the duration of µ-opioid activity. Delayed µ-opioid activity is believed to reduce a drug's abuse liability.
