I owuld wait until your hydro is wearing off and your body is asking for you (You know what I mean). Depending on your hydro useage, you should only take one or two tems at a time under your tounge but if you are a heavy user you might need more but these little white pills are very powerful.

I take 2 in the AM and one several times throughout the day and they work great.

PM if you need anything else!

ReOkie