Tone is correct. .

I'm not sure what book you have, but there is absolutely no siezure risk associated with hydrocodone or any other opiate/oid. There are siezure risks associated with the metabolite of Meperidine( Demerol ) , another synthetic, and closely related side-effects associated with the metabolite of propoxyphene ( Darvocet / Darvon ) Seizures, heart arrythmias (spelled incorrectly?)

"binding to µ-opioid receptors and inhibition of reuptake of norepinephrine and serotonin"

Monoamine. . what did you say?