I've never experienced nausea from the fioricet, but from the migraines themselves. I'm armed (and dangerous, lol j/k) with a couple forms of anti nausea meds to combat the nausea. It could be the caffeine, who knows, everyone is different. for some people caffeine doesn't help their migraines. Try drinking a cup of coffee or some cola and see if you get nauseated, then you'll know it's the caffeine and not just the fillers in a particular brand of fioricet. I knew somoene who could only take one brand of fioricet without getting ill. good luck, I sympathize with you.