I take 10/325s and I have also wondered what the long-term hazards are of this (I take 3 to 6 per day). I think the PDR says not to exceed 60 mg hydro per day (I'm going by memory here, so I may be wrong). I am going to ask the doc on my next consult.

Heli - I know you did not direct your question to me - but to tell you my experience - the only time I ordered hydro from an OP (NWW) I told them that I wanted 10/325 and they said OK. I have been prescribed hydro many times by my PCP and ENT doctor, and EVERY SINGLE TIME it is 5/500. That seems to be the standard for "moderate" pain, but I don't know.

Too bad we can't get 10/0. I've always wondered if they put the APAP in it to keep people from abusing it. From what I read, it seems like if you abuse it (for the hydrocodone) you die (from the APAP).