all I know is 3+ doctors & 3 + pharmacists I know in real life and have known for years have all said that generics are at least 20% less potent & depending on the manufacturer and or country they come from maybe more. adn there was soemthing bout different cheaper binders or soemthing being used also on generics. I just know me, myself can tell the difference bwteen a generic V and name brand and generic hydro vs name brand is all I know.