I was never a depressed person until my mother died and the severe pain set in. I take Effexor, and it is horrid. Prozac helped for a little while, but it pooped out. I am going to ask to get off Effexor/this sweating and feeling ill is not normal for me. The muscle twitching has left my left thumb almost paralyzed. My hands are turning into claws. I sense that I am going downhill very fast, but there is nothing to grab onto. Thanks to everyone who sympathized - Flavia