No, I would not make an issue out of it.

I would raise a big effing Stink about it. You have been given an inadequate substitution. In fact, I very much doubt that they can just substitute APAP for IBU, two totally different things. For one thing, APAP is more hepatotoxic, and for another, IBU is a much better anti-inflammatory (note, some real doctors (MDs) have actually described APAP to me as an anti-inflammatory, which I have a hard time believing)

Then the issue of being given 2.5 mg of Hydroco per pill less than prescribed; totally inadequate. If you have the prescription (or copy), then go back and insist on the proper meds.

If he has a reason (maliciously or no) to contend that you may have swapped the pills in the bottle for duds, in order to obtain more meds, then you may have a problem. I ran into this when I was given 100 dessicated, barely working, crumbly pills a few weeks ago. Unfortunately, I had no way of proving that those were the ones I had actually been given by the pharmacist, and so I will be stuck for one more week with some lousy pills.

Do what I am doing, and find a more conscientious pharmacist, and have a chat with the guy or lady at your new pharmacy of choice, just to get to know them a bit.

Best of luck to you,

Red