There was a good thread entitled hydro for stress relief and there was some discussion about use of opiates for treating depression. From my own experience and reading about others' experiences, it seems that hydro does lift your spirits while you're taking it, but as your tolerance builds or as you stop taking it, the rebound effect is pretty severe depression. I would like to know what other DB'ers have read or experienced on this subject. Also, are there any good painkillers that do not aggravate or bring on depression when you stop taking them?