depends on the doc, i'd guess. as far as migraines, my "neuro" categorically wouldn't write for anything stronger than tyley3's -- and these only as a last resort after trying cafergot, midrin, imitrex, maxalt, et al. So I went to a clinic (no referral, or anything) and met an "old school doc" who wrote for oxy's! well, you can guess who is now my primary care physician. even so, i am careful not to refill that oxy script as often as i actually need to. which brought me to DB... bottom line, for me is, Nothing Completely and Reliably works against the miniature bearded dwarves with pick-axes who live and work in my brain...