In the earlier days of treating pain, I found codeine T-4s, or even T-3s, quite effective. However, after an off and on regimen of "higher octane" PKs (hydro and oxy) for the relief of several injuries (since healed), I find that fairly large doses of pure codeine, and even various strengths and types of hydro, barely effective for the occasional severe backaches, headaches and misc. pains of a 50+ year old person.
I guess I'm wondering if, after ingesting the stronger pain meds, there is a permanent effect on the receptors of one's brain, if tolerance exists from here on out, despite long periods of abstinence. Do codeine and hydro become "bunk" forevermore hereafter following a year or so of intermittent prescriptions for percocets and it's cousins?
I hope this makes sense -- I just concluded a ten hour work shift.