I'v e talked to so many people who tell me 10/325's just don't do it for them, Im a strong beleive in 10/650 in fact Ive never even took a norco before and can say that I don't think Im missing much. I was prescribed VP from my doctor (local) and it knoked me on my yeah you know anyway there was something different about the VP that made relief more easy to find and at the same taking taking less APAP. Im thiking you need to up the APAP but not too much I guess it would dpend on how much you take in a days time. I'm off hydro for almost 8 days now, I do it every 6 weeks to bring myself to the fact that one day soon its got to give and Im going to need surgery to fix this problem in the long run (knee) I take it just to get in the shower before work but I cut myself off and not because I was out because I they weren't ''doing it'' for me but when I do go back (soon) Im sure the reilef will be there just as it was sometime ago. my small suggestion try a 10/500 or 10/650 they help me unless you think this might be a tolerance issue, good luck bro... Pm if you have any questions