Suggestion? It's not the meds - it's most likely tolerance or the 7.5/750's just work better for you because of the more APAP. It is not the meds. 10mg is 10mg is 10mg of hydrocodone. It wasn't the meds with Able either. There's no way you'd get 2 refills in a row of 2 different brands and both have something 'wrong' with them, that would be astronomical odds of that happening. My suggestion is to ask for a combo with higher APAP content on your next consult, maybe 10/500 or 10/650 - since the higher APAP seems to work better with you. You can't change meds mid-refills though so you will need to wait and ask next consult. That's about all you can do. Some people just don't like the 10/325's - but the 10mgs hydro is there - I think some people just get used to the taking of the equivalent of 2-3 Extra Strength tylenol along with their hydro and when that extra pain relief is not there it doesn't seem the same. And of course the other possibility would be tolerance or when you are taking the meds (don't take an hour before OR after eating - if you take food with meds just eat some crackers or a piece of toast or a few carrot sticks or something) Hope this helps.