Awful! I don't have bad reactions to much of anything, but the Remeron was so weird I can't even describe it...totally doped out, in the most unpleasant way, goofy, sleepy, but only sorta dozed, with bizarre semi-dreams. And I hadn't been taking anything else that might have interacted. My PMP had given me some samples, plus I filled a scrip. After 2 doses, I gave her back the samples And the scrip, told her she could do whatever with them. She was surprised, so I guess most folks are ok with it, but don't worry, you're not alone.