As someone once said to me - possibly, possibly, possibly.... but remember Adrenal Fatigue .... associated with these meds. I enjoy the reading (projections, theories, BUT the REMBER the LOCK AND KEY Fit - the pictures almost look the same - the difference between codiene and HYDROCODONE (or oxycodone - hydrocodone; I have not seen any flat 2 deminsional){codiene and hydrocodone an OH group) pictures - Hydroxyl OH or ONE HYDROGEN ATOM H+ the most simple of atoms - but the difference in absorption, crossing the BBB, and efficacy ... well look it up ... You have to look at the slightest differences (1 atom or more) and then the DIFFERENT SYSTEMS affected due to these 2 to 3 atoms here and there in a 3 dimensional structure... not a one page picture (two dimensional) ... of course I only had a few chemistry - - -courses .... and don't know as much as the pharmacologist posting here -sorry ... I guess - because I have seen them decribe their colleges and degrees ...and am impressed by all means.... thanks for the information folks ... Very interesting indeed ... I enjoy the different post concerning MOA's.