| WickedNoah |
| (Member) |
| 10/30/04 05:03 AM |
 Re: Opiate Treatment of Refractory Depression
|
Quote:
Is it that its partially an antagonist .... or is it just that its a weaker agonst so it seems like one when one takes it while already on a full opioid?
It means that it sits on the receptor for a long time without activating it very much. It also has a high affinity for opioids receptors, so it would preferentially bind instead of drugs that activate the receptor all the time. This replacement can cause withdrawal, but it also ensures you don't overdose.
Noah
