I was just put on hydromorphone for refractory depression about a month ago. I'd cal 18 years of every drug ln the market and ECT refractory. I was getting ready to kill myself by the end of the year. One of the major reasons it isn't used much is political. I don't feel hi at all. I just finally feel like I've enough energy to wash the dishes and do my laundry. If somehow I lose the docs doing the RXing I wil be dead in a couple of months. Thank goddess there are some brave souls out there.